Press Releases from Biopharma PEG Scientific Inc. (13 total)
Biopharma PEG Supplies Cholesterol (Plant-Derived) Used As Excipients for Lipid …
Cholesterol, a derivative of cyclopentane polyhydrophenanthrene, is the main steroid compound in mammals. Most of the traditional cholesterol comes from animal brainstem and lanolin, which is of animal origin and has the risk of carrying animal viruses. Biopharma PEG innovatively uses plant sterols as starting materials to prepare plant-derived cholesterol (CAS NO.: 57-88-5) through biological fermentation and green synthesis, eliminating the generation and carrying of viruses from the source.
Cholesterol has…
Development Trends And Potential Challenges of PROTACs
PROTAC technology has been in development for more than 20 years. PROTAC proof-of-concept studies date back to 2001, when Crews' team tested the possibility of artificially induced intracellular protein degradation with a peptide that was too large in molecular weight and required cells to penetrate the peptide to improve cell permeability. The discovery of the first small molecule PROTAC and the subsequent small molecule E3 ligand, reported in 2008, greatly…
ADC Drugs For Breast Cancer Treatment
Breast cancer is the malignant tumor with the highest morbidity and mortality among women worldwide. At present, the main therapeutic methods include surgery, chemotherapy, radiotherapy, endocrine therapy and targeted therapy, etc. The development and marketing of new drugs have far-reaching significance in improving the survival of breast cancer patients and changing the pattern of breast cancer treatment.
On February 24, 2023, The NMPA approved Enhertu, an injectable drug developed jointly by…
History Development of Hydrogels
Hydrogels are composed of hydrophilic polymers, whose three-dimensional network structure can not only absorb a large amount of water, but also be used to carry drugs. Hydrogels prepared with suitable materials have the characteristics of high biocompatibility, mechanical and viscoelastic control. Since the term was coined in the late 19th century, hydrogels have been widely used in drug delivery, wound dressing, tissue engineering, and hygiene products. This article mainly introduces…
Biopharma PEG Develops PEG Linkers for Antibody Drug Conjugates
Antibody-drug conjugate (ADC) is one of the fastest growing fields in tumor therapy, which consists of monoclonal antibody (Antibody), linker (Linker) and active drug (Payload). So far, there are only 15 drugs on the market in the world. However, with the development of some perfect antibody modification techniques, advanced site-specific coupling techniques and powerful small-molecule toxins, ADC drug research has mushroomed and a large number of ADC drugs are in…
High Quality PEG Raw Materials From Biopharma PEG
Polyethylene glycol (PEG) is a polyether compound derived from petroleum with many applications, from industrial manufacturing to medicine. PEG is also known as polyethylene oxide (PEO) or polyoxyethylene (POE), it has wide variety of applications depending on the length of the polymer chain and the molecular weight of the final polymer.
The synthesis of PEG is done by polymerizing ethylene oxide, the main ingredient in antifreeze, using a ring-opening…
The Path To The Development of COVID-19 mRNA Vaccines
Since the first successful application of messenger ribonucleic acid (mRNA) as a vaccine agent in clinical studies, many advances have been made in the field of mRNA therapeutic technology after nearly 30 years of development. Vaccines are essential tools for the prevention, control and/or eradication of infectious diseases and are an essential part of global public health programmes.
The development and approval of an effective coronavirus disease 2019 (COVID-19) vaccine…
9 Classes of Drug Conjugates: Characteristics, Development Progress And Future D …
In the field of targeted delivery of drug conjugates, the concept of the magic bullet was proposed more than a hundred years ago. Magic bullet drugs can specifically identify and kill cancer cells without harming normal cells. With the continuous progress of protein genetic engineering, chemical conjugation and other technologies, the field of targeted delivery of drug conjugates is not limited to antibody drug conjugates, and most structures with specific…
New Technology of PROTACs
Most of the drugs currently in clinical use are based on small molecules and use the "occupancy-driven" mode of action to inhibit the function of proteins and play a role in the treatment of diseases. Different from traditional small molecule inhibitors and antagonists, protein degradation technology has developed rapidly in recent years because of its ability to induce the degradation of therapeutic target proteins, providing a new idea for the…
Biopharma PEG Provides Monodisperse PEGs In Drug Development
Monodisperse PEG products usually are organic compounds with a molecular weight of less than 1000. Monodispersed PEG linkers are pure compounds with a single molecular weight. Monodisperse polyethylene glycol(PEG) molecular weight is fixed. It can not be obtained by polymerization. It must be by the appropriate reaction of the basic polyethylene glycol fragment.
With advancements in both synthetic and purification chemistry over the past two decades, monodispersed PEG linkers have become more commercially…
High Quality PEG Raw Materials From Biopharma PEG
Polyethylene glycol (PEG) is a polyether compound derived from petroleum with many applications, from industrial manufacturing to medicine. PEG is also known as polyethylene oxide (PEO) or polyoxyethylene (POE), it has wide variety of applications depending on the length of the polymer chain and the molecular weight of the final polymer.
The synthesis of PEG is done by polymerizing ethylene oxide, the main ingredient in antifreeze, using a ring-opening…
The Advantages of Monodisperse PEG From In Drug Development
Monodisperse PEG products usually are organic compounds with a molecular weight of less than 1000. Monodispersed PEG linkers are pure compounds with a single molecular weight. In contrast, polydisperse PEGs linkers contain variations in molecular weight with an average molecular weight. The use of polydisperse PEGs linkers in drug development has led to problems in biological applications due to steric hindrance and binding.
With advancements in both synthetic and purification chemistry over the…
What’re The Applications of 3D Printing in Drug Delivery
3D printing (3DP) technology has been repurposed to apply to pharmaceutical development, in recent years it has been used to produce tablets of personalized dosage and combine several prescriptions into one tablet. Future possible developments discuss methods of sustained release and the ability to integrate into sites of injury or trauma specifically to assist the healing process.
3D Bioprinting in History
First discovered and developed in the 1980s, 3DP is a relatively…
