Chronic Liver Disease Market Report 2032 | Major players involved- Novo Nordisk A/S, Madrigal Pharmaceuticals, Axcella Therapeutics, 89bio, expected to boost the market share

DelveInsight's "Chronic Liver Disease Market Insights, Epidemiology, and Market Forecast-2032" report delivers an in-depth understanding of Chronic Liver Disease, historical and forecasted epidemiology as well as the Chronic Liver Disease market trends in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom), and Japan.

The Chronic Liver Disease market report provides current treatment practices, emerging drugs, the market share of the individual therapies, and the current and forecasted Chronic Liver Disease market size from 2019 to 2032, segmented by seven major markets. The Report also covers current Chronic Liver Disease treatment practice/algorithm, market drivers, market barriers, and unmet medical needs to curate the best opportunities and assesses the underlying potential of the Chronic Liver Disease market.

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Key highlights from the chronic liver disease market report:
The chronic liver disease market is poised for transformation due to rising prevalence, enhanced diagnostic techniques, and evolving treatment options, including advancements in therapeutic offerings.

The primary treatment goal in chronic liver disease is to halt disease progression and manage complications. This involves correcting underlying causes, managing portal hypertension, and providing specific treatments for individual conditions. The burden of chronic liver disease is significant, largely due to the absence of effective approved pharmacological therapies.

The lack of drug approvals from regulatory agencies poses challenges for pharmaceutical market growth. Organ transplantation is typically reserved for patients with end-stage liver disease and is emerging as a substantial market in its own right.

However, there is optimism for new medications on the horizon. Semaglutide from Gilead Sciences, Inc. and Novo Nordisk A/S, along with Madrigal's lead candidate, Resmetirom (formerly MGL-3196), are among several early and mid-stage clinical candidates that are shaping the therapeutic landscape of chronic liver disease. These developments aim to address a wide range of unmet needs, including tackling underlying causes and managing associated complications.

Chronic Liver Disease Overview
Chronic liver disease (CLD) refers to long-term liver damage that can lead to liver failure, cirrhosis, and liver cancer. It encompasses a range of conditions that result in progressive liver injury and impaired liver function over time. Effective management is crucial to prevent complications and improve quality of life.

Causes
Chronic liver disease can arise from various factors, including:

Alcohol Abuse: Excessive alcohol consumption can lead to alcoholic liver disease.
Viral Infections: Hepatitis B and C viruses are significant contributors to chronic liver disease.
Non-Alcoholic Fatty Liver Disease (NAFLD): Associated with obesity, diabetes, and metabolic syndrome.
Autoimmune Diseases: Conditions such as autoimmune hepatitis can damage liver tissue.
Genetic Disorders: Conditions like hemochromatosis and Wilson's disease can lead to liver damage.
Chronic Biliary Diseases: Diseases affecting the bile ducts, such as primary biliary cholangitis and primary sclerosing cholangitis.
Signs and Symptoms
Symptoms of chronic liver disease may vary depending on the underlying cause but can include:

Fatigue: Persistent tiredness and lack of energy.
Jaundice: Yellowing of the skin and eyes due to elevated bilirubin levels.
Abdominal Pain: Discomfort or pain in the upper right abdomen.
Swelling: Ascites (fluid accumulation in the abdomen) and edema (swelling in the legs and ankles).
Itching: Generalized pruritus due to bile salt accumulation.
Dark Urine: Often accompanied by pale stools.
Nausea and Vomiting: Digestive disturbances may occur.
Confusion: Hepatic encephalopathy can lead to cognitive changes.
Diagnosis
Diagnosing chronic liver disease involves a combination of:

Medical History and Physical Examination: Assessment of symptoms, risk factors, and a physical exam.
Laboratory Tests:
Liver Function Tests: To assess liver enzymes and bilirubin levels.
Viral Hepatitis Testing: To identify hepatitis B or C infections.
Autoimmune Markers: For autoimmune liver diseases.
Imaging Studies: Ultrasound, CT scans, or MRI to visualize liver structure.
Liver Biopsy: In some cases, a biopsy may be performed to evaluate the extent of liver damage.
Treatment Options
Management of chronic liver disease focuses on addressing the underlying cause and preventing complications:

Lifestyle Changes:

Alcohol Cessation: For those with alcohol-related liver disease.
Weight Management: Important for patients with NAFLD.
Healthy Diet: A balanced diet low in saturated fats and sugars.
Medications:

Antiviral Drugs: For chronic hepatitis B and C infections.
Immunosuppressants: For autoimmune liver diseases.
Ursodeoxycholic Acid: For certain biliary conditions.
Regular Monitoring: Routine follow-ups to monitor liver function and assess for complications.

Surgery: In advanced cases, liver transplantation may be necessary for patients with liver failure or severe cirrhosis.

Supportive Care: Management of complications such as ascites, hepatic encephalopathy, and variceal bleeding.
Chronic liver disease is a serious condition that requires early diagnosis and comprehensive management. By addressing risk factors and underlying causes, patients can improve their liver health and quality of life. Regular medical care and lifestyle modifications are key components in managing this disease. If you suspect chronic liver disease, seek medical attention promptly.

Learn more about Chronic Liver Disease, treatment algorithms in different geographies, and patient journeys. Contact to receive a sample @ https://www.delveinsight.com/report-store/chronic-liver-disease-market?utm_source=openpr&utm_medium=pressrelease&utm_campaign=kpr


Chronic Liver Disease Market

The management of patients with Chronic Liver Disease depends on the stage of the liver disease. Liver fibrosis and cirrhosis result from underlying conditions like NASH, ALD, CHB, CHC, and others which progress to a stage of severity that becomes chronic due to the lack of standard treatment.

As per the guidelines from the American Liver Foundation, without any branded approvals, management of underlying comorbidity that is central to treating NASH and related fibrosis is of utmost importance. Various off-label therapies are used to manage Chronic Liver Disease complications, such as vitamin E (an antioxidant), insulin sensitizers (e.g., metformin, pioglitazone), anti-hyperlipidemic agents (e.g., gemfibrozil), pentoxifylline, and UDCA.

According to DelveInsight, the Chronic Liver Disease market is expected to witness considerable changes in the 7MM during the study period 2019-2032.

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Chronic Liver Disease Epidemiology Insights
According to Ginès et al. (2016), the prevalence of increased liver stiffness in the general adult population without previously known liver diseases ranges from 5.6% to 7.5%. This figure rises significantly among individuals with risk factors, reaching between 18% and 27%, indicating a concerning prevalence of chronic liver diseases in the general population.
Axley et al. (2018) classify fibrosis stages from F0 to F4, with advanced liver fibrosis (F3 and F4) serving as a critical predictor of disease progression and mortality. Current guidelines recommend screening for complications of cirrhosis once patients reach F3 fibrosis.
Additionally, Ginès et al. (2016) report that studies indicate 6-7% of adults without known liver disease have liver fibrosis, primarily linked to non-alcoholic fatty liver disease.

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Chronic Liver Disease Drugs Chapters

Chronic Liver Disease Drug Chapters
Emerging Drugs
While several late-staged and early-staged therapeutics are under development, the pharmaceutical product pipeline of Chronic Liver Disease is prolific. It includes leading pharma players in the pursuit of cracking the code in the protracted hepatology space.
Semaglutide: Novo Nordisk
Semaglutide is a selective GLP-1 receptor agonist given once daily, subcutaneously, for the treatment of non-alcoholic steatohepatitis (NASH). Based on studies, the development of Semaglutide in NASH is very much on track. It is currently in Phase III of its clinical development with a promise for closer to a solution that can be a potential launch in the hepatology space during the forecast period.
Resmetirom (formerly MGL-3196): Madrigal Pharmaceuticals
Madrigal's main attraction was its lead NASH compound, MGL-3196, a once-daily pill for fatty liver disease in-licensed from Roche, Resmetirom (formerly MGL-3196), a Phase III molecule that is a first-in-class, oral, once-daily formulation to target F2 and F3, and F4 stage patients. The company plans to file subpart H-accelerated approval for sooner entry into the market. This filling will be done based on recently published results; later, it will be continued by full NDA submission. Resmetirom also has FTD, which will help shorten the filling period. If all goes as planned, Resmetirom can be a potential launch in the hepatology space during the forecast period.

Chronic Liver Disease Pipeline Development Activities

The Chronic Liver Disease report provides insights into different therapeutic candidates in Phase II, and Phase III stages. It also analyses Chronic Liver Disease key players involved in developing targeted therapeutics.

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Chronic Liver Disease Therapeutics Assessment

Major key companies such as Novo Nordisk A/S, Madrigal Pharmaceuticals, Axcella Therapeutics, 89bio, and others are working proactively in the Chronic Liver Disease Therapeutics market to develop novel therapies which will drive the Chronic Liver Disease treatment markets in the upcoming years.

Learn more about the emerging therapies & key companies at: https://www.delveinsight.com/report-store/chronic-liver-disease-market?utm_source=openpr&utm_medium=pressrelease&utm_campaign=kpr


Chronic Liver Disease Report Key Insights

1. Chronic Liver Disease Patient Population
2. Chronic Liver Disease Market Size and Trends
3. Key Cross Competition in the Chronic Liver Disease Market
4. Chronic Liver Disease Market Dynamics (Key Drivers and Barriers)
5. Chronic Liver Disease Market Opportunities
6. Chronic Liver Disease Therapeutic Approaches
7. Chronic Liver Disease Pipeline Analysis
8. Chronic Liver Disease Current Treatment Practices/Algorithm
9. Impact of Emerging Therapies on the Chronic Liver Disease Market

Table of Contents

1. Key Insights
2. Executive Summary
3. Chronic Liver Disease Competitive Intelligence Analysis
4. Chronic Liver Disease Market Overview at a Glance
5. Chronic Liver Disease Disease Background and Overview
6. Chronic Liver Disease Patient Journey
7. Chronic Liver Disease Epidemiology and Patient Population
8. Chronic Liver Disease Treatment Algorithm, Current Treatment, and Medical Practices
9. Chronic Liver Disease Unmet Needs
10. Key Endpoints of Chronic Liver Disease Treatment
11. Chronic Liver Disease Marketed Products
12. Chronic Liver Disease Emerging Therapies
13. Chronic Liver Disease Seven Major Market Analysis
14. Attribute Analysis
15. Chronic Liver Disease Market Outlook (7 major markets)
16. Chronic Liver Disease Access and Reimbursement Overview
17. KOL Views on the Chronic Liver Disease Market
18. Chronic Liver Disease Market Drivers
19. Chronic Liver Disease Market Barriers
20. Appendix
21. DelveInsight Capabilities
22. Disclaimer

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