Acute Ischemic Stroke Pipeline, FDA Approvals, Clinical Trials Developments and Companies 2024 (Updated)

DelveInsight's, "Acute Ischemic Stroke Pipeline Insight 2024" report provides comprehensive insights about 35+ companies and 35+ pipeline drugs in the Acute Ischemic Stroke pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive Acute Ischemic Stroke pipeline products in this space.

Key takeaways from the Acute Ischemic Stroke Pipeline Report
• DelveInsight's Acute Ischemic Stroke pipeline analysis depicts a robust space with 35+ active players working to develop 35+ pipeline treatment therapies.
• The leading Acute Ischemic Stroke Companies include Genentech, Supergene, Tasly Pharmaceutical, Pharmazz, GNT Pharma, NoNO, Angde Biotech Pharmaceutical, NuvOx Pharma, Healios, Acticor Biotech, Biogen, ZZ Biotech, Revalesio Corporation, Shionogi & Co., Ltd., AbbVie, Pharming Group, Bristol-Myers Squibb, Roche, Clinuvel Pharmaceuticals, TrueBinding, Shin Poong Pharmaceutical, and others.
• Promising Acute Ischemic Stroke Pipeline Therapies include JTR-161, Tirofiban 0.05 MG/ML, YM872 (zonampanel), t-PA (alteplase), Intravenous ACT017 1000 mg, PP-007, Recombinant human urokinase, DLBS1033, Aspirin, Clopidogrel, natalizumab, DS1040b, and others.
• March 2024:- Biocells (Beijing) Biotech Co.,Ltd- A Multicentre, Randomised, Double-blind, Placebo-parallel Controlled Phase II Clinical Trial Evaluating the Efficacy and Safety of BXOS110 Injection in the Treatment of Acute Ischaemic Stroke Within 3 Hours of Onset.
• January 2024- Shanghai Hutchison Pharmaceuticals Limited- A Multicenter, Randomized, Double Blind, Placebo Controlled Phase II Clinical Study to Evaluate the Safety and Efficacy of SHPL-49 Injection in the Treatment of Acute Ischemic Stroke. This study is designed to determine the safety and efficacy of SHPL-49 intravenous infusion for 7 consecutive days in the treatment of acute ischemic stroke subjects.

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Acute Ischemic Stroke Overview
Acute ischemic stroke (AIS) is a medical emergency caused by decreased blood flow to the brain, which results in damage to brain cells. Acute ischemic stroke is a leading cause of death and disability in the US and affects approximately 7, 00,000 people each year. Signs and symptoms of stroke may include sudden-onset numbness or weakness in an arm or leg, facial droop, difficulty speaking or understanding speech, confusion, trouble with balance or coordination, and loss of vision.

Acute Ischemic Stroke Emerging Drugs Profile

• Nelonemdaz: GNT Pharma
Nelonemdaz is a moderate NR2B-selective N-methyl d-aspartate (NMDA) receptor antagonist and potent spin trapper that reduces NMDA receptor-mediated excitotoxicity and oxidative stress, two major routes of brain cell death leading to disability and death after stroke. Nelonemdaz previously showed better efficacy and a longer therapeutic time window than subtype-unselective NMDA antagonists or antioxidants alone in 5 animal models of stroke. Its safety and tolerability in humans has been established in two earlier phase I studies conducted in 165 healthy young and elderly volunteers in the US and China.

• Tenecteplase: Genentech
Tenecteplase (TNKase, TNK-tPA or TNK) is a thrombolytic agent derived from the tissue plasminogen activator (tPA), that binds fibrin and converts plasminogen to plasmin. It is a 527-amino acid glycoprotein developed by replacing three amino acids at the T, N and K positions of the glycoprotein structure of tPA under genetic recombinant technology. After replacing threonine 103 with asparagine, asparagine 117 with glutamine and a tetra-alanine at amino acids 296-299, TNK is about eightfold more potent in dissolving clot, 80-fold higher resistance to plasminogen activator inhibitor-1 and 14-fold enhanced relative fibrin specificity, and with a longer half-life (20 min).Hence, TNK is administered as a single intravenous bolus. Tenecteplase has a well-characterized mechanism of action with important practical advantages in administration and superior clinical efficacy for patients with large-vessel occlusion. It is currently being evaluated in imaging-eligible, late-window acute ischemic stroke (AIS) patients.

• SP-8203: Shin Poong Pharmaceutical
SP-8203, under development, is a new neuroprotective compound for acute ischemic stroke. It is a quinazoline-2, 4-dione derivative with multiple potent neuroprotective mechanisms of action including anti-inflammatory activities. Patent applications have been filed in 52 countries and granted in 44 countries. SP-8203, has proved as a first-in-class candidate which has a multiple neuroprotective effects through a variety of the stroke animal models. Particularly, because it extends the therapeutic window when combined with tPA, more patients would have the benefit of reducing cerebral infarction and edema as well as hemorrhage and mortality. In fact, a few years following by the project outset, SP-8203 won the top 10 future pharmaceutical special projects run by the Ministry of Health and Welfare, because it was highly evaluated for its distinctiveness. Currently, the drug is in Phase II stage of Clinical trial evaluation for the treatment of Acute Ischemic Stroke.

• NONO-SC: NoNO Inc.
NoNO-SC is a subcutaneously injectable nerinetide analog for the treatment of all strokes. Autoinjector compatibility (i.e. a "stroke pen") enables administration by any caregiver at home, en route to the hospital or upon arrival in the emergency department. Currently, the drug is in Preclinical stage of Clinical trial evaluation for the treatment of Acute Ischemic Stroke.

For further information, refer to the detailed Acute Ischemic Stroke Drugs Launch, Acute Ischemic Stroke Developmental Activities, and Acute Ischemic Stroke News, click here for Acute Ischemic Stroke Ongoing Clinical Trial Analysis- https://www.delveinsight.com/sample-request/acute-ischemic-stroke-ais-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=ypr

Acute Ischemic Stroke Pipeline Therapeutics Analysis
There are approx. 35+ key Acute Ischemic Stroke companies which are developing the Acute Ischemic Stroke therapies. The companies which have their Acute Ischemic Stroke drug candidates in the most advanced stage, i.e. phase III include, GNT Pharma.

Acute Ischemic Stroke Pipeline Segmentation

Phases
• Late stage products (Phase III)
• Mid-stage products (Phase II)
• Early-stage product (Phase I) along with the details of
• Pre-clinical and Discovery stage candidates
• Discontinued & Inactive candidates

Route of Administration
• Intra-articular
• Intraocular
• Intrathecal
• Intravenous
• Ophthalmic
• Oral
• Parenteral
• Subcutaneous
• Topical
• Transdermal

Molecule Type
• Oligonucleotide
• Peptide
• Small molecule

Find out more about the Acute Ischemic Stroke Pipeline Segmentation, Therapeutics Assessment, and Acute Ischemic Stroke Emerging Drugs @ Acute Ischemic Stroke Treatment Landscape- https://www.delveinsight.com/sample-request/acute-ischemic-stroke-ais-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=ypr

Scope of the Acute Ischemic Stroke Pipeline Report
• Coverage- Global
• Acute Ischemic Stroke Companies- Genentech, Supergene, Tasly Pharmaceutical, Pharmazz, GNT Pharma, NoNO, Angde Biotech Pharmaceutical, NuvOx Pharma, Healios, Acticor Biotech, Biogen, ZZ Biotech, Revalesio Corporation, Shionogi & Co., Ltd., AbbVie, Pharming Group, Bristol-Myers Squibb, Roche, Clinuvel Pharmaceuticals, TrueBinding, Shin Poong Pharmaceutical, and others.
• Acute Ischemic Stroke Pipeline Therapies- JTR-161, Tirofiban 0.05 MG/ML, YM872 (zonampanel), t-PA (alteplase), Intravenous ACT017 1000 mg, PP-007, Recombinant human urokinase, DLBS1033, Aspirin, Clopidogrel, natalizumab, DS1040b, and others.
• Acute Ischemic Stroke Pipeline Segmentation: Product Type, Molecule Type, Mechanism of Action

Dive deep into rich insights for drugs for Acute Ischemic Stroke Pipeline Companies and Therapies, click here @ Acute Ischemic Stroke Unmet Needs and Analyst Views- https://www.delveinsight.com/sample-request/acute-ischemic-stroke-ais-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=ypr

Table of Content
1. Introduction
2. Executive Summary
3. Acute Ischemic Stroke: Overview
4. Acute Ischemic Stroke Pipeline Therapeutics
5. Acute Ischemic Stroke Therapeutic Assessment
6. Acute Ischemic Stroke- DelveInsight's Analytical Perspective
7. Late Stage Products (Phase III)
8. Nelonemdaz: GNT Pharma
9. Drug profiles in the detailed report…..
10. Mid Stage Products (Phase II)
11. SP-8203: Shin Poong Pharmaceutical
12. Drug profiles in the detailed report…..
13. Early Stage Products (Phase I)
14. Drug name : Company name
15. Drug profiles in the detailed report…..
16. Preclinical and Discovery Stage Products
17. NONO-SC: NoNO Inc.
18. Drug profiles in the detailed report…..
19. Inactive Products
20. Acute Ischemic Stroke Key Companies
21. Acute Ischemic Stroke Key Products
22. Acute Ischemic Stroke Unmet Needs
23. Acute Ischemic Stroke Market Drivers
24. Acute Ischemic Stroke Market Barriers
25. Acute Ischemic Stroke- Future Perspectives and Conclusion
26. Acute Ischemic Stroke Analyst Views
27. Acute Ischemic Stroke Key Companies
28. Appendix

Got Queries? Find out the related information on Acute Ischemic Stroke Mergers and acquisitions, Acute Ischemic Stroke Licensing Activities @ Acute Ischemic Stroke Emerging Drugs, and Recent Trends- https://www.delveinsight.com/sample-request/acute-ischemic-stroke-ais-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=ypr

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